Medicine

Molecular distinction to refine operative and radiotherapeutic decision-making in meningioma

.MacFeeters Hamilton Neuro-Oncology Plan, Princess Or Queen Margaret Cancer Cells Centre, College Wellness Network and also Educational Institution of Toronto, Toronto, Ontario, CanadaJustin Z. Wang, u00c2 Vikas Patil, u00c2 Alexander P. Landry, u00c2 Chloe Gui, u00c2 Andrew Ajisebutu, u00c2 Jeff Liu, u00c2 Rebeca Yakubov, u00c2 Ramneet Kaloti, u00c2 Farshad Nassiriu00c2 &amp u00c2 Gelareh ZadehDivision of Neurosurgery, Department of Surgical Treatment, College of Toronto, Toronto, Ontario, CanadaJustin Z. Wang, u00c2 Alexander P. Landry, u00c2 Chloe Gui, u00c2 Farshad Nassiriu00c2 &amp u00c2 Gelareh ZadehPrincess Margaret Cancer Cells Centre, University Health And Wellness System, Toronto, Ontario, CanadaJustin Z. Wang, u00c2 Vikas Patil, u00c2 Alexander P. Landry, u00c2 Chloe Gui, u00c2 Andrew Ajisebutu, u00c2 Jeff Liu, u00c2 Rebeca Yakubov, u00c2 Ramneet Kaloti, u00c2 Farshad Nassiriu00c2 &amp u00c2 Gelareh ZadehDalla Lana University of Public Health, College of Toronto, Toronto, Ontario, CanadaOlli SaarelaNRG Oncology Studies and also Information Management Facility, Philadelphia, , USAStephanie L. Pughu00c2 &amp u00c2 Minhee WonTemerty College of Medicine, Educational Institution of Toronto, Toronto, Ontario, CanadaZeel PatelNeurosurgery Specialists of Tulsa, Tulsa, OK, USAChristopher WilsonDepartment of Nerve Surgical Treatment, Keck University of Medicine of the Educational Institution of Southern The Golden State, Los Angeles, CA, USAAaron Cohen-GadolDepartment of Nerve Surgical Operation, Indiana College Institution of Medication, Indianapolis, IN, USAMohamed A. ZaazoueDepartment of Orthopedic Surgical Operation, Washington University University of Medication in St. Louis, St. Louis, MONTH, USAMohamed A. ZaazoueGerman Cancer Consortium (DKTK), DKFZ Companion Site Tu00c3 1/4 bingen, Tu00c3 1/4 bingen, GermanyGhazaleh TabatabaiCluster of Excellence (EXC 2180) u00e2 $ Graphic Led and also Functionally Instructed Cyst Therapiesu00e2 $, Eberhard Karls College Tu00c3 1/4 bingen, Tu00c3 1/4 bingen, GermanyGhazaleh TabatabaiDepartment of Neurology as well as Interdisciplinary Neuro-Oncology, Center for Neuro-Oncology, Comprehensive Cancer Cells Facility, Hertie Institute for Professional Mind Research, Eberhard Karls College Tu00c3 1/4 bingen, Tu00c3 1/4 bingen, GermanyGhazaleh Tabatabai, u00c2 Sylvia C. Kurzu00c2 &amp u00c2 Paul PasslackDepartment of Neurosurgery, Center for Neuro-Oncology, Comprehensive Cancer Center, Eberhard Karls University Tu00c3 1/4 bingen, Tu00c3 1/4 bingen, GermanyMarcos Tatagiba, u00c2 Felix Behling, u00c2 Mirjam Renovanz, u00c2 Jens Schittenhelmu00c2 &amp u00c2 Paul PasslackDepartment of Pathology, University of San Francisco, San Francisco, CA, USADamian A. Almiron BonninHuman Biology Division, Fred Hutchinson Cancer Center, Seat, WA, USAEric C. HollandDepartment of Human Oncology, College of Wisconsin Hospitals and Clinics, Madison, WI, USATim J. KruserCentral Mind Growth Registry of the USA, Hinsdale, IL, USAJill S. Barnholtz-Sloanu00c2 &amp u00c2 Jill Barnholtz-SloanTrans Divisional Investigation Course (TDRP), Department of Cancer Public Health and also Genetic Makeup (DCEG), National Cancer Cells Institute, Bethesda, MD, USAJill S. Barnholtz-Sloanu00c2 &amp u00c2 Jill Barnholtz-SloanCenter for Biomedical Informatics &amp Information Technology (CBIIT), National Cancer Institute, Bethesda, MD, USAJill S. Barnholtz-Sloanu00c2 &amp u00c2 Jill Barnholtz-SloanPiedmont Brain Lump Center, Piedmonth Health Care Unit, Atlanta, GA, USAAndrew E. Sloanu00c2 &amp u00c2 Andrew E. SloanDepartment of Pathology, Northwestern Educational Institution, Evanston, IL, USACraig Horbinskiu00c2 &amp u00c2 Craig M. HorbinskiLou &amp Jean Malnati Human Brain Growth Principle at the Lurie Comprehensive Cancer Cells Facility, Northwestern Educational Institution, Evanston, IL, USACraig Horbinskiu00c2 &amp u00c2 Craig M. HorbinskiDepartment of Neurosurgery, Vanderbilt University Medical Center, Nashville, TN, USASilky Chotaiu00c2 &amp u00c2 Lola B. ChamblessDepartment of Laboratory Medication and also Pathobiology, Educational Institution of Toronto, Toronto, Ontario, CanadaAndrew GaoDivision of Neurosurgery, University of British Columbia, Vancouver, British Columbia, CanadaAlexander D. Rebchuku00c2 &amp u00c2 Serge MakarenkoDepartment of Pathology &amp Lab Medicine, Personnel of Medication, University of British Columbia, Vancouver, British Columbia, CanadaStephen YipDepartment of Neuropathology, Principle of Pathology, Ruprecht-Karls-University Heidelberg, Heidelberg, GermanyFelix Sahm, u00c2 Felix Sahmu00c2 &amp u00c2 Andreas von DeimlingClinical Teamwork Unit Neuropathology, German Cancer Research Center (DKFZ), Heidelberg, GermanyFelix SahmDepartment of Pathology, Leiden Educational Institution Medical Facility, Leiden, The NetherlandsSybren L. N. MaasDepartment of Pathology, Erasmus MC Cancer Cells Institute, Educational Institution Medical Facility Rotterdam, Rotterdam, The NetherlandsSybren L. N. MaasRadiation Medication Plan, Princess Margaret Cancer Centre, Toronto, Ontario, CanadaDerek S. TsangRadiation Oncology, Utah Cancer Cells Specialists, Salt Lake Area, UT, USAC. Leland RogersCenter for Cancer Cells Research, National Cancer Institute, Bethesda, MD, USAKenneth AldapeMiami Neuroscience Institute, Baptist Wellness, Miami, FL, USAMichael W. McDermottDepartment of Neurosurgery, Addenbrookeu00e2 $ s Hospital, Cambridge, UKThomas Santariusu00c2 &amp u00c2 Daniel M. FountainDepartment of Neurosurgery, University Hospitals Cleveland and also Case Western Book College, Cleveland, OH, USAWarren SelmanDepartment of Pathology, University Hospitals Case Medical Center, Cleveland, OH, USAMarta CouceDepartment of Neurosurgery, Centro Hospitalar Universitu00c3 u00a1 rio S. Jou00c3 u20a4 o, Porto, PortugalBruno CarvalhoCenter for Neuro-Oncology, Dana-Farber/Brigham and Womenu00e2 $ s Cancer Center, Boston, MA, USAPatrick Y. WenDepartment of Neurosurgery, Fight It Out College, Durham, NC, USAKyle M. WalshDepartment of Neurosurgery, Erasmus MC Cancer Cells Principle, Erasmus Educational Institution Medical Facility, Rotterdam, The NetherlandsEelke M. BosDepartment of Neurosurgery, Brigham and Womenu00e2 $ s Healthcare facility, Harvard Medical Institution, Boston, MA, USAWenya Linda BiDepartment of Radiology, Brigham and also Womenu00e2 $ s Healthcare facility, Dana-Farber Cancer Institute, Harvard Medical University, Boston, MA, USARaymond Y. HuangDepartment of Neurology, Department of Neuro-Oncology, Massachusetts General Hospital, Harvard Medical Institution, Boston Ma, MA, USAPriscilla K. BrastianosDepartment of Radiation Oncology, Massachusetts General Medical Center, Boston, MA, USAHelen A. ShihDepartment of Neurology, Hermelin Mind Lump Facility, Henry Ford Health, Detroit, MI, USATobias WalbertDepartment of Neurosurger, Hermelin Brain Lump Facility, Holly Ford Health And Wellness, Detroit, MI, USAIan Lee, u00c2 Ana Valeria Castro, u00c2 Houtan Noushmehru00c2 &amp u00c2 James M. SnyderDepartment of Pathology, University of Texas Medical Division, Galveston, TX, USAMichelle M. FelicellaDepartment of Neurosurgery, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, ItalyFrancesco Dimecou00c2 &amp u00c2 Andrea SaladinoNeuropathology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, ItalyBianca PolloDepartment of Neurosurgery, LMU Teaching Hospital, LMU Munich, Munich, GermanyChristian Schichoru00c2 &amp u00c2 Ju00c3 u00b6 rg-Christian TonnDepartment of Radiation Oncology, Charitu00c3 u00a9 u00e2 $ "Universitu00c3 $ tsmedizin Berlin, Corporate Participant of Freie Universitu00c3 $ t Berlin and Humboldt-Universitu00c3 $ t zu Berlin, Berlin, GermanyFelix EhretDepartment of Radiology, Mayo Center, Rochester, MN, USATimothy J. KaufmannDepartment of Lab Medicine and Pathology, Mayonnaise Facility, Rochester, MN, USADaniel H. Lachance, u00c2 Caterina Gianniniu00c2 &amp u00c2 Aditya RaghunathanDepartment of Oncology, Department of Medical Oncology, Mayo Medical Clinic, Rochester, MN, USAEvanthia GalanisDepartments of Neuro-Oncology and Neurosurgery, Moffitt Cancer Cells Facility, Tampa Florida, FL, USAMichael A. VogelbaumNeuropathology Device, Surgical Neurology Branch, National Principle of Nerve Ailments and also Movement, National Institutes of Health And Wellness, Bethesda, MD, USAPatrick J. CiminoDepartment of Nerve Surgical Operation, Northwestern College, Northwestern Medication, Chicago, IL, USAMark YoungbloodDepartment of Pathology, NYU Langone Medical Center, New York, NY, USAMatija SnuderlDepartment of Radiation Oncology, NYU Langone Health, New York Educational Institution, The Big Apple, NY, USAErik P. SulmanDepartment of Neurosurgery, Educational Institution of Oklahoma Health Sciences Facility, Oklahoma Metropolitan Area, OK, USAIan F. DunnPeninsula Schools of Medication as well as Dental Care, Plymouth College, Plymouth, UKC. Oliver HanemannDepartment of Neurosurgery, Royal University of Surgeons in Ireland, Dublin, IrelandMohsen JavadpourDepartment of Anatomical and also Cell Pathology, Chinese Educational Institution of Hong Kong, Shatin, Hong KongHo-Keung NgDepartment of Individual Genes, Educational Institution of The Golden State, Los Angeles, Los Angeles, CA, USAPaul C. BoutrosDepartment of Neurosurgery, College of California, Los Angeles, Los Angeles, USARichard G. EversonDepartment of Neurosurgery, University Hospital of Larissa, School of Medication, Educational Institution of Thessaly, Larissa, GreeceAlkiviadis Tzannisu00c2 &amp u00c2 Konstantinos N. FountasDepartment of Neurosurgery, University Medical Center Regensburg, Regensburg, GermanyNils Ole SchmidtDepartment of Surgical Treatment, Department of Neurosurgery, University of Alberta, Edmonton, Alberta, CanadaKarolyn AuCenter of Neurosurgery, Division of General Neurosurgery, University of Perfume, Cologne, GermanyRoland GoldbrunnerDepartment of Neurology, Personnel of Medication, Teaching Hospital Perfume, University of Fragrance, Fragrance, GermanyNorbert GalldiksLaboratory for Neurooncology and Experimental Neurosurgery, Division of General Neurosurgery, Center for Neurosurgery, Fragrance, GermanyMarco TimmerDepartment of Neurosurgery, Teaching Hospital of Copenhagen-Rigshospitalet, Copenhagen, DenmarkTiit Illimar MathiesenDepartment of Neurosurgery, College Medical Facility Hamburg-Eppendorf, Hamburg, GermanyManfred Westphal, u00c2 Katrin Lamszusu00c2 &amp u00c2 Franz L. RicklefsDepartment of Neurosurgery, Teaching Hospital Heidelberg, Heidelberg, GermanyChristel Herold-Mende, u00c2 Christine Jungku00c2 &amp u00c2 Gerhard JungwirthDepartment of Radiation Oncology, Heidelberg Teaching Hospital, Heidelberg, GermanyMaximilian DengLeeds Principle of Medical Research Study at St. Jamesu00e2 $ s, College of Leeds, Leeds, UKSusan C. ShortDepartment of Neurosurgery, The Walton Center NHS Structure Trust Fund, Liverpool, UKMichael D. JenkinsonInstitute of Neuropathology, Otto-Von-Guericke-University, Magdeburg, GermanyChristian MawrinDepartment of Neurosurgery, Manchester Facility for Scientific Neurosciences, Salford Royal Health Center NHS Foundation Trust, Salford, UKAbdurrahman I. Islimu00c2 &amp u00c2 Omar N. PathmanabanDepartment of Neurosurgery, Royal Melbourne Medical Facility, Melbourne, VIC, AustraliaKatharine J. Drummondu00c2 &amp u00c2 Andrew MorokoffDepartment of Radiation Oncology, Educational Institution of California, San Francisco, San Francisco, CA, USADavid R. RaleighDepartment of Neurosurgery, Educational Institution of California, San Francisco, San Francisco, CA, USADavid R. Raleighu00c2 &amp u00c2 Nicholas A. ButowskiDepartment of Pathology, College of The Golden State, San Francisco, San Francisco, CA, USADavid R. Raleighu00c2 &amp u00c2 Arie PerrySchool of Drug Sciences of Ribeiru00c3 u20a4 o, Preto College of Su00c3 u20a4 o Paulo, Su00c3 u20a4 o Paulo, BrazilTathiane M. MaltaDepartment of Pathology and also Lab Medicine, College of Saskatchewan University of Medication, Saskatoon, Saskatchewan, CanadaViktor ZherebitskiyDivision of Neurosurgery, Royal University Hospital, College of Saskatchewan, Saskatoon, Saskatchewan, CanadaLuke HnennyUSC Pituitary Facility, USC Radiosurgery Center, Keck College of Medication of USC, Los Angeles, CA, USAGabriel ZadaDepartment of Neurosurgery, St. Barbara-Klinik Hamm-Heessen, Hamm, GermanyAntonio SantacroceNuclear Medicine and Medical Molecular Image Resolution, Team of Radiology, Eberhard Karls College of Tu00c3 1/4 bingen, Tu00c3 1/4 bingen, GermanyChristian Los Angeles Fougu00c3 u00a8 reDepartment of Neurosurgery, Yale University of Medication, New Place, CT, USAJennifer MoliternoDepartment of Neurosurgery, Tufts Medical Center, Boston Ma, MA, USAAlper DincerArthur and Sonia Labatt Human Brain Tumour Research Facility, The Healthcare Facility for Sick Youngster, Toronto, Ontario, CanadaGelareh ZadehManuscript writing, figure preparation, overall statistical review as well as basic bioinformatics were performed through J.Z.W. Molecular category, design building and bioinformatics assist was supplied through V.P., A.P.L. and J.L. TERT marketer sequencing was actually done by C.G. Replicate number variant study and also referring to as were actually carried out by A.P.L. Molecular analyte origin, quantification and also sequencing were actually performed by J.Z.W., A.P.L., C.G., A.A. and also Z.P. DKFZ methylation training class and also subdivision resolution was actually executed by R.Y. and R.K. making use of the openly offered online tool made by F.S. RNA sequencing study was executed by V.P. as well as J.L. Biostatistical assessment was actually done by O.S. Medical records from the NRG Oncology RTOG-0539 meningioma situations were given through S.L.P. and also M.W. Clinical meningioma samples and also matching professional records were actually given by C.W., A.C.G., M.A.Z., G.T., M.T., F.B., D.A.A.B., E.C.H., J.B.S., A.E.S., C.H., S.C., L.B.C., A.R., S.M. and also S.Y. Pathologic testimonial was actually executed by A.G. and also K.A. Radiotherapy information of institutional retrospective meningioma instances were actually given by D.S.T. Study design and conception were done by J.Z.W, F.N. and also G.Z. All authors participated in document evaluation as well as modifications in some capacity.

Articles You Can Be Interested In